Development of a non-invasive diagnostic method for oxygen deficiency based on real-time measurement of methane and nitrous oxide
Goals
- Developing a non-invasive diagnostic method that enables the early detection of oxygen deficiency or ischemia in the gastrointestinal tract by measuring breath gases (CH4, N2O, and CO2)
- Scientifically demonstrate that changes in these breath gases are reliably associated with blood flow and microcirculation in the GI tract, as assessed in animal models and human studies
- Developing a clinically applicable prototype capable of measuring these gases in real time, with the long-term goal of bedside use in clinical practice
Specifically
- Measuring stable isotope values and concentrations of CH4, N2O and CO2 from collected breath gas samples of human studies and animal models with high accuracy
- Investigations into NO3- to N2O conversion in mammalian cells
Project Lead
- Prof. Mihály Boros, Institute for Surgical Research, University of Szeged, Hungary
- Prof. Frank Keppler & Maurice Maas (PhD Student), Research Group Biogeochemistry, Heidelberg University, Germany
- Prof. Zoltán Bozóki, Department of Optics and Quantum Electronics, University of Szeged, Hungary
- Prof. Andrey Kozlov, Ludwig Boltzmann Institute for Traumatology, Vienna, Austria
Cooperation Partners
- Dr. Reinhard Well & Dr. Caroline Buchen-Tschiskale, Thünen Institute of Climate-Smart Agriculture, Brunswick, Germany
Funding
- HU-RIZON, International Research Excellence Cooperation Programme of the National Research, Development and Innovation Office, Hungary
Activities & Progress
- Analysis and evaluation of measurements of the isotopic composition and concentrations of CH4, N2O, and CO2 in breath gas samples from animal models and human studies
